Need to grasp the principles of choosing medicinal plastic bottles
Nowadays, medicinal plastic bottles are available in many sizes, ranging from a dozen milliliters to a large one thousand milliliters. They are colorless, transparent, diverse in color, various in shape, and numerous in variety. In the face of the exciting plastic bottle market, as a pharmaceutical manufacturer, the following principles should be grasped when selecting plastic bottles:
Select the main raw material of plastic bottle, additive formula: the product standard of solid plastic bottle, respectively stipulate the applicable main raw materials, and must meet the requirements of non-toxic, no odor, etc., due to the variety of main raw materials available, this It is necessary to select the comprehensive properties of the raw materials. Generally, the high-density polyethylene and polypropylene bottles are used for the tablets. If the transparency is required, PET bottles are required. For example, if the drug needs higher barrier properties and is blocked or opaque, the brown PET bottle is used. The barrier performance is better for PEN bottles. Liquid dosage forms generally use polypropylene or polyester bottles as the main raw material.
The sealing property of the bottle body and the cover, and the water vapor permeability. Sealability and water vapor permeability are two important technical indicators for pharmaceutical plastic bottles, which play an important role in the stability of the charge.
Plastic bottle product quality standards. From the product quality standards of the production plant, the quality of the product can be analyzed and judged. Pharmaceutical plastic bottle enterprises should set enterprise standards that are stricter than national standards and industry standards.
Quality Assurance System. Auditing suppliers has become an essential part of the procurement of plastic bottles. Through auditing, a comprehensive and correct assessment of the software and hardware facilities, technical equipment and quality level of the production plant can be made.
The stability and compatibility of the plastic bottle. The selection of plastic bottles, especially for new drugs, should be carried out in a charge test to investigate the stability of the charge and the compatibility between the plastic bottle and the drug. The penetration, dissolution, adsorption, chemical reaction and denaturation of drugs and plastic bottles must be determined by scientific testing.
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